The product in focus in today’s post is such a guilty pleasure.

Similarly to other skincare enthusiasts, I have a love-hate relationship with the anti-aging cream by Skinceuticals – Triple Lipid Restore 2:4:2. It’s soo good! Yet, so expensive too!

I got it for Christmas last year and loved it for three whole months. But didn’t have the heart (nor the bank account balance) to buy it.

The bad news?
There’s nothing quite like it currently on the market – I discuss it in detail below.

The good news?
You can get a similar product for your day-to-day needs (I list the best alternatives below), and save this amazing moisturizer for only when your skin needs its powers the most.

Let me show you my top-rated Skinceuticals Triple Lipid Restore alternatives that I’ve managed to find since then.

Why people love the Skinceuticals Triple Lipid Restore

Before we get into the list of similar products, perhaps it’s worth exploring what’s so unique about the Skinceuticals Triple Lipid Restore cream in the first place. This will help us compare other products to it later on.

What the product is:
The cream is a unique symbiosis of ceramides, cholesterol, and fatty acids. It therefore effectively minimizes the appearance of wrinkles and fine lines and helps your skin barrier to restore its health by replenishing it with important building blocks.

In addition, the cream also reduces pore size and makes your face look evened out and healthy. It can restore and protect the skin’s natural moisture barrier.

There’s a reason why this product is called the Triple Lipid Restore 2:4:2 cream. It contains:

  • 2% ceramides
  • 4% cholesterol
  • 2% fatty acids

These three ingredients are all lipids found in the skin but get diminished with age. They’re essential for the maintenance of healthy skin and the balance between these lipids also helps restore the skin’s barrier and retain moisture.

Skinceuticals have actually patented this formula and have done extensive testing to ensure its effectiveness. There’s nothing quite like it on the market, unfortunately.

The important thing about the formula is that it combines ceramides, cholesterol, and fatty acids in just the right amount to get the most out of these individual ingredients.

You see, the combo of these three in the proper quantities is what’s effective to repair the skin barrier.

Studies have shown that if used individually or in the wrong ratios, the ingredients can actually delay skin restoration. Whereas if used in the right mix, your skin can see a rapid recovery.

That’s why this cream is so expensive and costs around $160 for a 1.63 oz jar (48ml).

INCI list:

Aqua/​Water/​Eau, Dimethicone, Hydrogenated Polyisobutene, Glycerin, Cholesterol, C12-15 Alkyl Benzoate, Ceramide 3, Helianthus Annuus Seed Oil Unsaponifiables/​Sunflower Seed Oil Unsaponifiables, Bis-Peg-18 Methyl Ether Dimethyl Silane, Sodium Polyacrylate, Peg-10 Dimethicone, Nylon-12, Lauryl Peg-9 Polydimethylsiloxyethyl Dimethicone, Dimethicone/​Peg-10/​15 Crosspolymer, Phenoxyethanol, Disteardimonium Hectorite, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Chlorphenesin, Caprylyl Glycol, Peg/​Ppg-18/​18 Dimethicone, Propylene Carbonate, Disodium Edta, Acrylonitrile/​Methyl Methacrylate/​Vinylidene Chloride Copolymer, Adenosine, Dipropylene Glycol, Lavandula Angustifolia Oil/​Lavender Oil, Rosmarinus Officinalis Leaf Oil/​Rosemary Leaf Oil, T-Butyl Alcohol, Mentha Piperita Oil/​Peppermint Oil, Sodium Citrate, Linalool, Isobutane, Ceramide Eop, Bht, Tocopherol, Limonene

Notable features:

  • The cream can be described as an all-in-one hydrating anti-aging cream.
  • Created for dry and mature skin, this is one of the most-loved age-defying solutions that provide extensive hydration to the skin without irritating it.
  • Regular users share that their skin radiance has improved, their pore appearance is reduced, and overall the skin feels smooth and even with consistent use.

Why isn’t there an exact replacement for the Skinceuticals Triple Lipid Restore moisturizer?

So, as you’ve already read – Skinceuticals’ cream is pretty unique in its formulation and it has been proven to work – which is exactly why it’s so expensive.

And, unfortunately, as of now there are no other brands that have managed to emulate the formula and achieve something similar.

In the following list of alternatives of the Skinceuticals Triple Lipid Restore moisturizer, you’ll see products that have a similar feel, and perhaps some similarities in the ingredients lists.

However, none of these is an exact or very close alternative, I’m afraid.

So, if you can afford the Skinceuticals product and are enjoying the results – by all means, do continue to use it.

You can save some money by only applying it in winter or when your skin has gone through tough times, such as after a procedure or a chemical peel. I’ve managed to stretch mine for up to six months of occasional use.

And for your daily needs, you can choose one of the following replacements for the Skinceuticals Triple Lipid Restore.

5 more affordable alternatives to Skinceuticals Triple Lipid Restore

Top choice: Replenix Age Restore Nighttime Therapy

Replenix - Triple Lipid Restore Dupe

The first Skinceuticals Triple Lipid Restore replacement that I’d like to introduce you to is the top choice from this list – the Replenix Age Restore Nighttime Therapy Cream.

What is it?
This anti-aging night cream is infused and blended with some of the most advanced, dermatologist-developed ingredients that have the power to revive, restore, and renew the skin.

The product’s core mission is to increase skin elasticity, boost plumpness, increase collagen levels, and deliver a youthful skin appearance.

Some of the core ingredients that help achieve all this include ceramides – to nourish and repair the skin barrier, peptides – to plump up the skin and support collagen production, reducing fine lines and wrinkles, and green tea polyphenol – a powerful antioxidant that soothes and calms irritated skin, and protects it from external harm.

The product also contains squalane, which helps further with skin moisture retention and barrier protection.


  • The formula is designed to protect the skin barrier and restore the skin’s elasticity with consistent use.
  • The product itself is highly moisturizing and deeply hydrates the skin while not being too heavy and oily.
  • The antioxidants in the ingredient list help protect against free radicals and environmental damage.
  • Fine lines and wrinkles are reduced with regular use due to the plumping ingredients and the use of peptides – a group of compounds known for their anti-aging benefits.
  • The product makes the skin look and feel soft and firm.

What we like:

  • The Replenix Age Restore Nighttime Therapy Cream is an excellent (and the closest, in my experience) alternative to the Skinceuticals original as it comes in a similarly rich, nourishing texture with a luxurious feel to it.
  • The cream is unscented and therefore suitable for everyone, even for sensitive skin.
  • Just like the original Skinceuticals product, this replacement cream also contains cholesterol to support the skin barrier.
  • The price point is more affordable, with a price of around $95 for a 1.69 oz jar (50ml).

What to have in mind:

  • Considering the size of the package, the product remains on the pricy end of the spectrum, although it’s significantly cheaper.
  • Some users share that they have experienced breakouts after using the product. This could be a result of a lack of information or a poor choice of product for a specific skin type. For example, it shouldn’t be expected for it to be well tolerated by oily and acne-prone skin because it contains a lot of occlusive ingredients.

Replenix Age Restore Nighttime Therapy is Available at Amazon, SkinStore, Lookfantastic, Dermstore and Planet Beauty.

Cheapest: CeraVe Skin Renewing Night Cream

Skinceuticals Triple Lipid Restore vs CeraVe

You may have come across the Skinceuticals Triple Lipid Restore vs CeraVe debate before. This is because the CeraVe Skin Renewing Night Cream is a popular replacement due to the many similarities that they have.

What is it?
The CeraVe substitute for Skinceuticals is another renewing cream designed for night use that comes with three essential ceramides (1, 3, and 6) and peptides.

The rich ingredient list of the CeraVe also includes hyaluronic acid, which locks in moisture and hydrates the skin.

In addition, it’s packed with niacinamide, which brightens the skin and improves the complexion.

The product also contains cholesterol, just like Skinceuticals, allantoin – which soothes the skin, and tocopherol – a powerful antioxidant.


  • Minimizes the appearance of fine lines and wrinkles with consistent use.
  • Makes the skin look smoother and feel softer due to its outstanding moisturizing abilities.
  • Offers excellent protection for the skin’s natural barrier with triple ceramide content and the use of antioxidants.
  • This cream is extremely suitable for sensitive skin and the brand is amongst the most recommended by dermatologists.

What we like:

  • The product only costs a fraction of what you would pay for the Skinceuticals original yet you get a decent amount of it – 1.7 fl oz (50 ml) for about $18 – by far the most affordable Skinceuticals Triple Lipid Restore alternative in my list.
  • There is no fragrance in the product so it’s suitable for sensitive skin types.
  • The product is non-comedogenic and can be used by acne-prone people safely.
  • I personally love the rich, creamy texture that this has. I definitely see immediate results the morning after I use it – my skin feels soft and well-moisturized without having an oily film to it.

What to have in mind:

  • Some people share that the cream is a bit too rich, especially for oily skin. I would say that people with dry and normal skin will enjoy it best.
  • The product is a budget alternative and naturally, it’s not as potent as Skinceuticals. However, if you’re looking for a cheap price, this is perhaps the best alternative you can go for.
  • This is a straightforward evening moisturizer with no frills in it. If you’re after a more luxurious feel, this won’t be your best match.

Epionce Medical Barrier Cream

Epionce - products similar to Skinceuticals Triple Lipid Restore

Another Skinceuticals Triple Lipid Restore alternative is the Epionce Medical Barrier Cream. It has a thicker texture that aids dry and flaky skin.

What is it?
This is another product rich in glycerin, and ceramides, packed with antioxidants like safflower seed oil, exfoliants like gluconolactone, and cholesterol – it has a plethora of skin-loving ingredients that will pamper your skin.

It’s super soothing thanks to the presence of bisabolol and Alteromonas ferment extract in the ingredient list. In fact, it’s great to use after a chemical peel or other invasive procedures.


  • This cream offers outstanding hydration, specifically designed for sensitive and dry skin types.
  • Improves the visible effects of aging and reduces the appearance of fine lines and wrinkles with frequent use due to all the moisturizing and plumping ingredients in it.
  • It gives radiance and smoothes the skin immediately after the first use.
  • The product contains gluconolactone, a PHA exfoliant with a large molecular structure that will gently exfoliate the topmost layer of the skin. PHA exfoliants are amongst the most tolerated by all skin types, as they are the mildest.
  • Gluconolactone also helps to repair the impaired skin barrier, has anti-aging capabilities, and is moisturizing, too.

What we like:

  • The cream is completely free from parabens, fragrances, sulfates, and gluten – it is gentle on sensitive and sensitized skin.
  • It’s very affordable, costing only around $50 for an 8 oz tub (237 ml).
  • The formula is rich in beneficial ingredients and you can feel the difference from the very first application.

What to have in mind:

Oily people, be mindful that just like some other products on this list, this one leans on the heavier side and might be too much for you.

Epionce Medical Barrier Cream is Available on Amazon, SkinStore and Dermstore.

SkinFix Barrier Triple Lipid-Peptide Cream

Another high-quality product similar to Skinceuticals is the SkinFix Barrier Triple Lipid-Peptide Cream. I came to know of this product from a dermatologist that I follow on social media – Dr. Samantha Ellis although she didn’t recommend it as a replacement per se. Do follow her, if you’re interested in skin care, she posts invaluable information daily.

What is it?
This alternative is a moisturizing, nourishing cream that offers a lot of similarities to the expensive Skinceuticals original.

The product contains a 3% Triple Lipid Complex, 3% Peptide Protein Blend, and 3% Seaweed Hyaluronate Blend.

The combo makes the skin soft, brightens the skin tone, and smoothes out any imperfections. Some of the key ingredients in the mix include shea butter, jojoba oil, rice extract, squalene, carrageenan extract, hyaluronic acid, ceramides, and cholesterol.

It comes in a 1.7 fl oz jar (50 ml) and is vegan and cruelty-free.


  • This cream is highly agreeable with most skin needs. For sensitive skin types – it has none of the common irritants such as alcohol, fragrance, silicones, etc. And acne-prone skin types can rest assured that it’s non-comedogenic.
  • The product is great at supporting and restoring your moisture barrier due to all the beneficial ingredients in it.

What we like:

  • Although the ingredient list is quite complex and diverse, the ingredients in the product are non-aggressive and the formula is well-tolerated by most.
  • This is a pH-balanced product similar to the Skinceuticals moisturizer that will sustain the natural pH levels of your skin.
  • The product is much more suitable for sensitive skin than Skinceuticals as it doesn’t contain any essential oils.
  • The packaging is great – the airless push-pump jar keeps the product safe from bacteria and is amongst the handiest ones that I’ve personally used.
  • Despite the richness, this cream absorbs well without leaving a shine on your skin. Your face will be silky smooth.

What to have in mind:

Although it’s much cheaper than the Skinceuticals original, this cream may still be considered rather expensive for some people.

SkinFix Barrier Triple Lipid-Peptide Cream is Available on Amazon and Feelunique.

Stratia Liquid Gold

Stratia - Skinceuticals Triple Lipid Restore alternative

With this last alternative for Skinceuticals Triple Lipid Restore, we’re rounding up the list. This is another skin-loving moisturizer that is more on the lightweight side, so, oily skin folks – stay tuned!

What is it?
As a brand created by a founder who was intrigued by the outstanding properties and skincare benefits of ceramides, cholesterol, and fatty acids, Stratia certainly doesn’t disappoint. The Stratia Liquid Gold is an excellent Skinceuticals replacement that is considered one of the bestsellers of the brand.

It offers skin restoration and anti-aging properties in a light formula suitable for daily use.

Some of the key ingredients in the formula include rosehip oil, which is considered a natural alternative to retinol – a powerful anti-aging ingredient.

The product also contains niacinamide, tocopherol, cranberry seed oil, green tea extract, and sodium hyaluronate. This mix helps the product be soothing, restoring, and rejuvenating for your skin.


  • Moisturizes in-depth and helps restore the skin’s natural hydration while not being heavy on the skin.
  • Significantly minimizes the appearance of fine lines and wrinkles with the help of all the plumping and moisturizing ingredients in combination with antioxidants.
  • Protects the skin barrier and helps it build resilience. Calms inflamed skin and nourishes in depth.
  • Due to the lack of fragrance and alcohol, this moisturizer is safe for sensitive skin types.

What we like:

  • I loved the texture of this product, which is very lightweight and easy to apply. My oily-prone skin loved how quickly it absorbs, how moisturized the skin feels, and how no greasy residue was left on the skin.
  • The product is designed for all skin types and is a perfect choice for people looking for a high-quality moisturizer for a lower price point – it costs about $27 for a 2 oz bottle (60 ml).
  • I personally love the addition of rosehip oil – it’s amongst the most well-tolerated oils for all skin types and can truly work great against signs of aging. Even with it infused in this cream, the product impresses with its lightness.

What to have in mind:

The Stratia Liquid Gold is not necessarily as occlusive as the other options in this list so people with very dry skin might not find it that great. Though, oily folks will love it.

There we have them – the winners in the list of top alternatives for the Skinceuticals Triple Lipid Restore cream.

They are all much more affordable in terms of price. At the same time, they offer a lot of similar effects to the expensive original.

If you have tried some of these alternatives, I’d love to hear your thoughts on them. Or maybe you’ve used another product that is not on this list? Let me know below!